About Us
The Centre for Integrative Immune Analysis (CIIA) is an immune profiling core at the University Health Network, delivering scalable and modular assays and services to support immunology research across pre-clinical, translational and clinical studies. Our clients and collaborators include researchers at UHN, as well as external academic and industry partners.
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SERVICES
From samples to immunological insights, the CIIA provides a comprehensive selection of scalable, modular services, including sample processing, handling and storage, single-cell and spatial immune profiling, and integrated data analysis. Our platform supports studies using patient samples, with select capabilities also available for pre-clinical mouse studies.
EVENTS
The CIIA hosts workshops and events. Explore upcoming events and registration details below.
OPPORTUNITIES
The CIIA is proudly committed to supporting the next generation of scientists and researchers through co-op, summer student and volunteer opportunities that provide hands-on experience in a dynamic research laboratory setting.
Publications
Select a publication title to read the full article.
Pembrolizumab and stereotactic body radiotherapy combined in advanced hepatocellular carcinoma post sorafenib – A phase II trial (PEMRAD).
O’Kane GM, Mesci A, Jang RW, Barry A, Bocaya CM, Boukhaled GM, Acton H, Doddington D, Rodrigo R, Chan LML, Noamani B, Harvey H, Elia A, Law R, Prince R, Doherty M, Dodd A, Wong DK, Wang L, Wang BX, Chen EX, Dawson LA, Knox JJ.
JHEP Rep. 2025 Nov 1;8(2):101658.
Binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations: results from the Phase II BEAVER trial
Rose AAN, Maxwell J, Rousselle E, Mukonoweshuro CL, Elkholi IE, Riaud M, Biondini M, Cianfarano E, Soria-Bretones I, Tobin C, McGuire M, Law RWY, Elia AJ, Wang BX, King I, Zhang T, Pugh TJ, Kamil ZS, Butler M, Shepherd FA, Leighl NB, Razak AA, Hansen A, Saibil SD, Bedard PL, Siegel PM, Siu LL, Cescon DW, Spreafico A.
Nat Commun. 2026 Jan 3;17(1):1323.
Cross-Cancer Analysis Reveals a Distinct Pattern of Immune Modulation During Curative Radiation Therapy
Said BI, Boukhaled GM, Lok BH, Lukovic J, Mesci A, Waldron J, Wong P, Wang BX, Brooks DG, Milosevic M.
Int J Radiat Oncol Biol Phys. 2026 Feb 1;124(2):441-450.
CD28-driven ex vivo generation of stem-like memory CD8+ T cells bypassing CD3/TCR signaling.
Ihara F, Ohashi Y, Zheng EYF, Fukao S, Rodrigo R, Noamani B, Boukhaled GM, Wang BX, Han DH, Wei X, Burt BD, Saso K, Matsunaga Y, Ly D, Kagoya Y, Butler MO, Mak TW, Saibil SD, Hirano N.
Proc Natl Acad Sci U S A. 2026 Apr 28;123(17):e2524626123.
Contact Us
Please contact us by email at any time to discuss your research needs. The CIIA provides support throughout the entire project lifecycle, from experimental design, protocol development, and grant applications to sample processing, data acquisition, analysis, and interpretation. Whether you are planning a new study or have samples or datasets ready for analysis, our team is here to help.
CIIA@UHN.CA